Related Experiment Video
Updated: Jul 28, 2026
08:53
Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney
Published on: August 9, 2014
[Growth factors: a regulator of renal function].
K Yoshioka1, K Murakami, S Maki
1Department of Pediatrics, Kinki University School of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|December 1, 1992
Summary
Epidermal growth factor (EGF) and insulin-like growth factor (IGF) play key roles in kidney function and disease. Their regulation impacts renal cells, hemodynamics, and disease states like ischemic injury and hypertrophy.
Area of Science:
- Nephrology
- Endocrinology
- Molecular Biology
Background:
- Epidermal growth factor (EGF) and insulin-like growth factor (IGF) are critical signaling molecules.
- Renal expression and function of EGF and IGF are integral to kidney homeostasis.
- Dysregulation of these growth factors is implicated in various kidney diseases.
Purpose of the Study:
- To review the roles of EGF and IGF in regulating renal function.
- To explore the association of EGF and IGF with kidney diseases.
- To highlight the physiological actions and expression patterns of renal EGF and IGF.
Main Methods:
- Immunohistochemical analysis of EGF and EGF-receptor distribution in human kidneys.
- Review of existing literature on EGF and IGF roles in renal physiology and pathology.
- Analysis of gene expression patterns in experimental models.
Main Results:
- EGF is mitogenic for tubular cells, affects salt/water reabsorption, and influences glomerular hemodynamics.
- Altered renal EGF expression is observed in ischemic injury, hypertrophy, and cystic diseases.
- IGF-I stimulates tubular gluconeogenesis, is mitogenic for mesangial cells, and increases glomerular filtration rate.
Conclusions:
- EGF and IGF are vital regulators of kidney function with diverse physiological effects.
- Aberrant expression of EGF and IGF is linked to the pathogenesis of renal diseases.
- Further research into EGF and IGF signaling may offer therapeutic targets for kidney disorders.
More Related Videos
Related Concept Videos
01:33Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
01:24Regulation of Angiogenesis and Blood Supply
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...
01:28Role of Hematopoietic Growth Factors
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Thrombopoietin (TPO), mainly released by the liver,...
01:13Introduction to Urinary System
The urinary system consists of two kidneys, two ureters, the urinary bladder, and the urethra.
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
The kidneys are bean-shaped organs located in the retroperitoneal space, on either side of the vertebral column, between the T12 and L3 vertebrae. They are partially protected by the rib cage and surrounded by perirenal fat, which provides cushioning. They are responsible for urine formation and play critical roles in regulating blood pressure, electrolyte levels, and hormone production. The ureters...
01:28Glomerular Filtration Rate and its Regulation
The Glomerular Filtration Rate (GFR) is a measure of kidney function, reflecting the volume of filtrate formed per minute in the kidneys. On average, GFR is approximately 125 mL/min in males and 105 mL/min in females. Maintaining a relatively constant GFR is essential for the kidneys to effectively regulate body fluid homeostasis and maintain extracellular stability.
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
The myogenic...
01:11Renal Failure: Dose Adjustments
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...