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[Enzymatic ocular hypertension: a statistical study (author's transl)].

J L Menezo, M Marco, E V Mascarell

    Journal Francais D'Ophtalmologie
    |April 1, 1978
    PubMed
    Summary
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    The use of alpha-chymotrypsin in cataract surgery significantly increases the risk of ocular hypertension, affecting 40.3% of patients compared to 25.3% without the enzyme. This pressure elevation persists for at least three weeks post-operation.

    Area of Science:

    • Ophthalmology
    • Surgical Science
    • Pharmacology

    Context:

    • Cataract surgery is a common procedure.
    • Alpha-chymotrypsin is an enzyme sometimes used during cataract surgery.
    • Ocular hypertension is a potential complication following eye surgery.

    Purpose:

    • To statistically analyze the incidence of ocular hypertension after cataract surgery.
    • To compare outcomes between patients who received alpha-chymotrypsin and those who did not.
    • To evaluate the impact of alpha-chymotrypsin on post-operative intraocular pressure.

    Summary:

    • A statistical study compared two groups of cataract surgery patients: 1,003 with alpha-chymotrypsin and 324 without.
    • Intraocular pressure was measured 24-48 hours post-operation.

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  • Results showed a higher incidence of ocular hypertension in the alpha-chymotrypsin group (40.3%) versus the control group (25.3%), persisting for three weeks.

    • Impact:

    • The findings suggest that alpha-chymotrypsin use is associated with an increased risk of post-operative ocular hypertension.
    • This highlights the need for careful patient selection and monitoring when using this enzyme.
    • Further research may explore alternative enzymatic agents or modified surgical techniques to mitigate this risk.