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Acute tolerance to nitrous oxide in humans.

Douglas S Ramsay1, Arthur C Brown, Stephen C Woods

  • 1Department of Psychology, University of Washington, Seattle, WA 98195 USA School of Dentistry, University of Washington, Seattle, WA 98195 USA The Oregon Health Sciences University School of Dentistry, Portland, OR 97201 USA.

Pain
|December 1, 1992
PubMed
Summary

Nitrous oxide effectively raises pain and detection thresholds in dental patients initially. However, its analgesic effect is inconsistent, with some patients developing acute tolerance during prolonged use.

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