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L-dopa inhibits in vitro phosphorylation of melanoma glycoproteins
1Department of Microbiology, Immunology and Molecular Genetics, Albany Medical College, New York 12208.
Pigment Cell Research
|December 1, 1992
Abstract:
L-DOPA had no effect on the endogenous phosphorylation of proteins after extraction with 1% Triton X-100 from hamster melanoma. When proteins were purified further by wheat germ-agglutinin chromatography, however, a dramatic and dose-dependent inhibitory effect of DOPA on glycoprotein phosphorylation was observed in the presence of Mn+2.