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Related Experiment Videos

Measles: lessons from an outbreak.

I Gurevich1, R A Barzarga, B A Cunha

  • 1Infectious Disease Division, Winthrop-University Hospital, Mineola, NY 11501.

American Journal of Infection Control
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

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Hospital measles outbreaks reveal inadequate immunity guidelines. Doubling enzyme-linked immunosorbent assay (ELISA) titers and revaccinating staff improved protection against measles transmission.

Area of Science:

  • Infectious Disease Epidemiology
  • Hospital Infection Control
  • Vaccinology

Background:

  • Measles outbreaks pose significant challenges for hospital infection control, affecting patients and healthcare personnel.
  • Existing guidelines for managing measles outbreaks among hospital staff are unclear and insufficient.

Observation:

  • An investigation of a measles outbreak in a university-affiliated teaching hospital revealed substantial staff exposure.
  • Four initial cases led to 607 staff exposures and two secondary infections, necessitating furloughs and vaccinations for 47 and 88 personnel, respectively.

Findings:

  • Established serologic criteria for measles immunity proved inadequate during the outbreak.
  • Minimal enzyme-linked immunosorbent assay (ELISA) antibody titers were insufficient to prevent secondary transmission.

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Implications:

  • Adjusting serologic immunity thresholds, such as doubling ELISA titers, may be necessary during hospital measles outbreaks.
  • Revaccination strategies leveraging the anamnestic response can enhance protection in healthcare workers with low measles antibody titers.
  • Revised guidelines are needed to effectively manage measles immunity and prevent outbreaks in healthcare settings.