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Updated: Aug 8, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
Published on: May 2, 2025
[Platelet adenylate cyclase activity in alcoholics]
T Saito1, M Watanabe, Y Katamura
1Department of Neuropsychiatry, Sapporo Medical College, Hokkaido, Japan.
Abstract:
Platelet adenylate cyclase (AC) activity in the long-term abstinent alcoholics, who maintained abstinence from alcohol for at least one year was examined. Guanine nucleotide [Gpp(NH)p] stimulated AC activity was not changed in platelet membrane from long-term abstinent alcoholics. However, the extent of AC activity induced by 250 mM ethanol in vitro, in the presence of 1 microM Gpp(NH)p, was significantly reduced in platelet membrane from long-term abstinent alcoholics. These results suggest that platelet AC activity may be a biological marker for alcoholics.
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