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[IgA nephropathy (Berger's disease) in children]
L Velásquez-Jones1, J R Sánchez-Aguilar, G Ramòn-Garcia
1Departamento de Nefrología, Hospital Infantil de México Federico Gómez, D.F.
Boletin Medico Del Hospital Infantil De Mexico
|December 1, 1992
Summary
IgA nephropathy, or Berger's disease, in children often presents with hematuria. Some cases show improvement with treatment, while others may progress without intervention.
Area of Science:
- Nephrology
- Immunology
Context:
- IgA nephropathy (Berger's disease) is a kidney disorder characterized by IgA deposits in the glomeruli.
- It often manifests as recurrent gross or persistent microscopic hematuria.
Purpose:
- To describe the clinical presentation, treatment outcomes, and prognosis of IgA nephropathy in a cohort of seven pediatric patients.
Summary:
- Most children presented with recurrent macroscopic hematuria and proteinuria, without significant hypertension or renal impairment.
- Four patients received no treatment, with varied outcomes including remission, improvement, or persistent symptoms.
- One patient with significant proteinuria improved with prednisone and azathioprine; another with rapidly progressive glomerulonephritis improved with intensive immunosuppressive therapy.
Impact:
- Highlights the variable clinical course of IgA nephropathy in children.
- Suggests potential benefits of immunosuppressive therapy in specific cases, particularly those with rapidly progressive disease or significant proteinuria.