Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Glomerular changes in diabetes mellitus.

E D Schleicher¹, B Olgemöller

¹Institut für Diabetesforschung, München.

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies

|October 1, 1992

Summary

Diabetic kidney complications involve changes in extracellular matrix, like increased collagen type IV and decreased heparan sulfate proteoglycan. Hyperglycemia is the primary cause, though exact mechanisms require further study.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Spinal muscular atrophy : Time for newborn screening?]

Der Nervenarzt·2017

Same author

IL-6 deficiency in mice neither impairs induction of metabolic genes in the liver nor affects blood glucose levels during fasting and moderately intense exercise.

Diabetologia·2010

Same author

Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in the liver of mice is related to plasma glucose levels after acute exercise.

Diabetologia·2010

Same author

Dissection of biochemical borderline phenotypes in carriers and genetic variants of medium-chain acyl-CoA dehyrogenase deficiency: implications for newborn screening [corrected].

Clinical genetics·2009

Same author

Selective association of plasma non-esterified fatty acid species with circulating interleukin-8 concentrations in humans.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association·2008

Same author

Increased levels of HPV16 E6*I transcripts in high-grade cervical cytology and histology (CIN II+) detected by rapid real-time RT-PCR amplification.

Cytopathology : official journal of the British Society for Clinical Cytology·2007

Area of Science:

Nephrology
Diabetology
Biochemistry

Background:

Diabetic late complications affect kidney structure and function.
Extracellular matrix alterations are key events in diabetic nephropathy.

Purpose of the Study:

To investigate changes in extracellular matrix components in diabetic kidneys.
To explore the link between hyperglycemia and diabetic nephropathy.

Main Methods:

Ultrastructural, immunohistochemical, and biochemical analyses of diabetic kidneys.
Use of antibodies against extracellular matrix components.

Main Results:

Increased collagen type IV deposition and decreased heparan sulfate proteoglycan in the mesangial matrix and glomerular basement membrane.
Correlation between extracellular matrix alterations and nephropathy severity.
Collagen type III presence indicates irreversible glomerular changes.

Conclusions:

Hyperglycemia is the primary cause of diabetic nephropathy.
Alterations in extracellular matrix components contribute to renal dysfunction.
Further research is needed to fully understand pathobiochemical mechanisms, including the polyol pathway.

Related Experiment Videos