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[Preclinical changes in left ventricular function in obesity. An angioscintigraphic study].

G Gorini1, F Sessa, R Casucci

  • 1Dipartimento di Medicina Interna e Terapia Medica, Università degli Studi di Pavia.

La Clinica Terapeutica
|November 1, 1992
PubMed
Summary

Obesity is linked to early heart disease, specifically diastolic dysfunction, even with normal systolic function. This study used equilibrium pool scintigraphy to identify these early cardiac changes in obese individuals.

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Area of Science:

  • Cardiology
  • Nuclear Cardiology
  • Cardiovascular Disease

Background:

  • Obesity is a growing global health concern associated with cardiovascular complications.
  • Early detection of cardiac abnormalities in obesity is crucial for timely intervention.
  • Diastolic dysfunction may precede overt heart failure in obese individuals.

Purpose of the Study:

  • To investigate diastolic function in obese subjects using equilibrium pool scintigraphy.
  • To compare diastolic filling indices between obese individuals and normal controls.
  • To determine if diastolic abnormalities are an early indicator of obesity-linked heart disease.

Main Methods:

  • Equilibrium pool scintigraphy was conducted on 11 obese subjects (BMI 34 +/- 2) and 14 normal controls.

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  • Data underwent temporal and spatial smoothing, followed by time-activity curve generation.
  • A semiautomatic second derivative edge-detection algorithm was used to calculate the one-third filling fraction, an index of diastolic filling.

    • Main Results:

    • The one-third filling fraction, representing diastolic filling, was significantly reduced in obese subjects compared to controls.
    • Obese subjects exhibited diastolic abnormalities despite maintaining normal systolic function (Ejection Fraction = 65 +/- 5%).

    Conclusions:

    • Diastolic dysfunction may be an early manifestation of obesity-linked heart disease.
    • These findings suggest that nuclear cardiology techniques can detect subclinical cardiac changes in obesity.
    • Early identification of diastolic abnormalities can guide preventative strategies for cardiovascular health in obese populations.