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Electrocardiographic changes in scrub typhus patients.

C Y Fang, D T Dennis, J B Lee

    The Southeast Asian Journal of Tropical Medicine and Public Health
    |December 1, 1977
    PubMed
    Summary
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    Electrocardiogram (ECG) abnormalities are common in scrub typhus, particularly during the acute febrile stage. Prompt antibiotic treatment effectively prevents serious cardiac complications in scrub typhus patients.

    Area of Science:

    • Cardiology
    • Infectious Diseases
    • Internal Medicine

    Background:

    • Scrub typhus, a zoonotic disease caused by Orientia tsutsugamushi, can lead to cardiac complications.
    • Electrocardiography (ECG) is a key diagnostic tool for assessing cardiac involvement.

    Observation:

    • Ninety-eight scrub typhus patients underwent ECG examinations during acute and convalescent stages.
    • ECG findings were compared to 101 asymptomatic healthy individuals.

    Findings:

    • Common ECG abnormalities in scrub typhus included sinus arrhythmia, flat/low T waves, sinus tachycardia, ST segment elevation, prominent U waves, tall/peaked T waves, incomplete right bundle branch block, T wave inversion, first-degree AV block, and QTc prolongation.
    • Certain abnormalities like flat T waves, tall/peaked T waves, and sinus arrhythmia were more frequent in scrub typhus patients compared to controls.

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  • ECG abnormalities were most prevalent during the acute phase of the illness.

    • Implications:

    • The study highlights the significant cardiac impact of scrub typhus.
    • Findings suggest that early antibiotic intervention is crucial for mitigating severe cardiac sequelae, as observed prior to the antibiotic era.