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Related Experiment Videos

Delayed-type hypersensitivity responses regulate collagen deposition in the lung.

R Kimura1, H Hu, J Stein-Streilein

  • 1Department of Medicine, University of Miami School of Medicine, FL 33101.

Immunology
|December 1, 1992
PubMed
Summary

Delayed-type hypersensitivity (DTH) drives hapten-immune pulmonary interstitial fibrosis (PIF) in hamsters. This T-lymphocyte-mediated lung inflammation, dependent on cutaneous DTH, leads to increased lung collagen and non-resolving PIF.

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Area of Science:

  • Immunology
  • Pulmonary Medicine
  • Toxicology

Background:

  • Previous studies linked epicutaneous 2,4,6-trinitrochloro-1-benzene (TNCB) immunization to pulmonary interstitial fibrosis (PIF) upon lung challenge with 2,4,6-trinitrobenzene sulphonic acid (TNBS).
  • The immunological mechanisms underlying hapten-induced PIF, specifically the role of delayed-type hypersensitivity (DTH), require further investigation.

Purpose of the Study:

  • To investigate the immunological mechanisms contributing to increased lung collagen in hapten-immune hamsters challenged with trinitrophenol (TNP).
  • To evaluate the hypothesis that DTH modulates lung response to TNP, leading to PIF, by comparing cutaneous DTH and lung collagen deposition.

Main Methods:

  • Comparison of cutaneous DTH response (48 hours post-challenge) with lung collagen deposition (14 days post-challenge) in different hamster strains (LSH and LVG).

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  • Assessment of sex-based differences in susceptibility to hapten-immune pulmonary interstitial fibrosis (HIPIF) in LSH hamsters.
  • Evaluation of age-related effects on DTH and PIF in LVG hamsters.

    • Main Results:

    • The inbred LSH strain, a high DTH responder to TNP, developed non-resolving PIF (termed HIPIF).
    • Female LSH hamsters exhibited higher susceptibility to TNP-induced HIPIF than males.
    • Young LVG hamsters were low DTH responders and did not develop PIF, while mature LVG hamsters with DTH reactivity developed PIF.

    Conclusions:

    • Lung collagen deposition in hapten-immune hamsters is regulated by T-lymphocyte-mediated DTH in the lung.
    • The development of HIPIF is dependent on the capacity to mount a cutaneous DTH reaction to the hapten.
    • Understanding DTH-mediated PIF mechanisms is crucial for assessing risks from environmental chemicals causing skin and lung diseases.