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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
09:17

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[Pharmacokinetic, bacteriological and clinical studies on cefprozil in pediatric patients]

S Arai1, R Sono, M Ito

  • 1Department of Pediatrics, School of Medicine, Mie University.

The Japanese Journal of Antibiotics
|November 1, 1992
PubMed

Insights

Cefprozil (CFPZ) demonstrates potent antibacterial activity comparable to other antibiotics. This new oral cephem antibiotic proved 100% effective and safe in pediatric patients with various infections.

Area of Science:

  • Pharmacology
  • Microbiology
  • Pediatrics

Background:

  • Cefprozil (CFPZ) is a novel oral cephem antibiotic.
  • Antibiotic resistance and efficacy are critical concerns in pediatric infectious diseases.

Purpose of the Study:

  • To evaluate the antibacterial spectrum, pharmacokinetics, and clinical efficacy of Cefprozil (CFPZ) in pediatric patients.
  • To assess the safety profile of Cefprozil (CFPZ) in this population.

Main Methods:

  • Antibacterial activity of CFPZ was tested against 11 clinical isolates from 6 species.
  • Pharmacokinetic parameters including serum concentration and urinary excretion were measured after oral administration (15 mg/kg).
  • Clinical efficacy and safety were assessed in 25 pediatric patients with infections.

Main Results:

  • CFPZ exhibited antibacterial activity equal to or greater than Cefaclor (CCL) against Staphylococcus aureus, alpha-hemolytic Streptococcus, Escherichia coli, and Haemophilus influenzae.
  • Peak serum concentrations of CFPZ were achieved within 1-2 hours post-administration, with a 6-hour urinary excretion rate of 33.8%.
  • A 100% efficacy rate was observed in 25 pediatric patients, with 15 excellent and 10 good responses. Adverse events were mild, including soft stool and transient laboratory abnormalities.

Conclusions:

  • Cefprozil (CFPZ) is a highly effective oral antibiotic against common pediatric pathogens.
  • CFPZ demonstrates favorable pharmacokinetic properties and a strong safety profile for use in pediatric infectious diseases.

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