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[Multiple meningiomas in different compartments of the cerebrospinal axis]
M Zumkeller1, V Seifert, H Dietz
1Neurochirurgische Klinik, Medizinische Hochschule Hannover.
Abstract:
Multiple meningeomas in the absence of Recklinghausen's disease are rare and usually occur in a single compartment of the neuroaxis. Multiple meningeomas in different neuroaxial compartments are an even rarer condition, only a few cases having been reported. We describe four cases, each with two meningeomas in different compartments of the neuroaxis. Their peculiarity consists in the fact that the different tumours developed at different times and locations in the supratentorial and spinal regions. The radiological and operative findings are described. The possibility of dissemination via the cerebrospinal fluid or blood or of a multifocal origin or genetic predisposition is discussed.
Insights
Multiple meningiomas in different neuroaxial compartments are exceptionally rare. This study details four unique cases of meningiomas occurring in distinct brain and spinal regions at different times.
Area of Science:
- Neurosurgery
- Oncology
- Neuropathology
Background:
- Multiple meningiomas, typically confined to one neuroaxial compartment, are uncommon.
- Meningiomas occurring in separate supratentorial and spinal compartments are exceedingly rare, with few documented instances.
Observation:
- This report presents four distinct cases of patients with multiple meningiomas.
- Each case featured two meningiomas located in different neuroaxial compartments (supratentorial and spinal).
- Tumor development occurred asynchronously and in separate locations within these compartments.
Findings:
- Radiological and operative findings for each case are detailed.
- The study explores potential etiologies including cerebrospinal fluid or hematogenous dissemination.
- Multifocal origin and genetic predisposition are considered as possible causes.
Implications:
- Highlights the rare occurrence of multiple meningiomas across different neuroaxial compartments.
- Contributes to understanding the potential pathways of meningioma spread or multifocal development.
- Informs clinical suspicion and diagnostic approaches for rare presentations of meningioma.