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Related Experiment Videos

Multidrug resistant enteric fever.

R Chandra1, S Srinivasan, P Nalini

  • 1Department of Paediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

The Journal of Tropical Medicine and Hygiene
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

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Multidrug-resistant typhoid fever (MDRT) presents significant challenges, with prolonged fever and higher complication rates observed. Fluoroquinolones like ciprofloxacin offer effective treatment for MDRT, demonstrating rapid response and cost-effectiveness.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Multidrug-resistant typhoid fever (MDRT) poses a growing public health concern in South India.
  • Typhoid fever remains a significant infectious disease globally, with increasing antimicrobial resistance.

Purpose of the Study:

  • To review cases of multidrug-resistant typhoid fever in a pediatric population.
  • To identify clinical features and treatment outcomes of MDRT.

Main Methods:

  • Retrospective review of pediatric cases admitted to JIPMER Hospital, Pondicherry in 1990.
  • Analysis of clinical presentation, blood culture results, and antibiotic efficacy.

Main Results:

  • Striking features included prolonged pyrexia, toxaemia, and tender hepatomegaly.

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  • Higher incidence of complications and persistent bacteraemia were noted.
  • Resistance to multiple antibiotics was common; fluoroquinolones showed best efficacy.

    • Conclusions:

    • MDRT cases exhibit distinct clinical characteristics and increased complications.
    • Fluoroquinolones, particularly ciprofloxacin, are recommended for effective MDRT treatment.
    • Cefotaxime demonstrates moderate efficacy in managing MDRT.