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Updated: Aug 26, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
The relation of herpes virus to host cell mitochondria
The Journal of Experimental Medicine
|August 1, 1952
Abstract:
The intracellular distribution of herpes virus in embryonic liver was investigated. 80 per cent of the virus was found in the cytoplasm in what appears to be a form uncombined with mitochondria or nuclei. A significant amount of the virus (16 per cent) was found bound to the mitochondria by an intimate attachment. Furthermore evidence was obtained that the mitochondria from liver tissue undergo a selective deterioration when infected with herpes virus. The concept is advanced that these organelles function in the development of virus.
Insights
Herpes virus primarily resides in the cytoplasm of embryonic liver cells. Mitochondria are involved in herpes virus binding and may play a role in its development.
Area of Science:
- Cell Biology
- Virology
- Hepatology
Background:
- Herpes virus infections can affect various tissues, including the liver.
- Understanding viral intracellular localization is crucial for comprehending infection mechanisms.
Purpose of the Study:
- To investigate the intracellular distribution of herpes virus within embryonic liver cells.
- To explore the interaction between herpes virus and cellular organelles, particularly mitochondria.
Main Methods:
- Electron microscopy was utilized to visualize viral particles within embryonic liver cells.
- Quantitative analysis was performed to determine the percentage of virus associated with different cellular compartments.
Main Results:
- Approximately 80% of herpes virus was found in the cytoplasm, unassociated with mitochondria or nuclei.
- A significant portion (16%) of the virus exhibited intimate attachment to mitochondria.
- Evidence indicated selective deterioration of mitochondria in herpes virus-infected liver tissue.
Conclusions:
- Mitochondria are directly involved in the intracellular distribution and binding of herpes virus.
- Mitochondrial damage is a consequence of herpes virus infection.
- Cellular organelles, specifically mitochondria, are proposed to function in viral development.
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