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[Effect of short-term use of omega-3-type polyunsaturated fatty acids in subjects with hypertriglyceridemia]
F B Naber1, M Oudkerk Pool, T Teerlink
1Afd. Inwendige Geneeskunde, Academisch Ziekenhuis Vrije Universiteit, Amsterdam.
Objective:
To study the effect of omega-3 polyunsaturated fatty acid supplementation on lipid profile in hypertriglyceridaemic patients.
Setting:
General practice.
Design:
Prospective, double blind study of 12 weeks' duration.
Patients And Methods:
Eight patients received fish oil (1800 mg C20: 5 omega-3 eicosapentaenoic acid (EPA) and 1200 mg C22:6 omega-3 docosahexaenoic acid (DHA). Nine patients received corn oil (3000 mg C18: 2 omega-6 linoleic acid daily).
Results:
Lipid profile analysis showed a decrease in triglyceride levels after fish oil supplementation. An unexpected and unexplained finding was the rise in total cholesterol and LDH cholesterol with corn oil supplementation.
Conclusion:
Fish oil causes a decrease in triglyceride levels in hypertriglyceridaemic patients.