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Acute uric acid nephropathy in pregnancy
E Alexopoulos1, P Tampakoudis, H Bili
1First Department of Obstetrics and Gynecology, Aristotelian University of Thessaloniki, Hippokration General Hospital, Greece.
Background:
Although uric acid clearance increases during gestation, uric acid nephropathy is a rare cause of acute renal failure in the pregnant woman.
Case:
A 38-year-old woman experienced acute renal failure due to acute uric acid nephropathy at 30 weeks' gestation. The diagnosis was based on extreme hyperuricemia and an elevated uric acid-creatinine ratio. Treatment with forced diuresis, urine alkalinization, and mannitol infusion resulted in a prompt and complete recovery of renal function. The woman ultimately gave birth to a healthy child.
Conclusion:
Acute uric acid nephropathy during pregnancy responds to conventional medical therapy.