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Fetal stroke associated with elevated maternal anticardiolipin antibodies
R K Silver1, S N MacGregor, J F Pasternak
1Department of Obstetrics and Gynecology, Evanston Hospital, Northwestern University Medical School, Illinois.
Obstetrics and Gynecology
|September 1, 1992
Summary
Middle cerebral artery infarction can cause congenital hemiparesis. In two cases, elevated maternal anticardiolipin antibodies after delivery suggest a link to intrauterine thromboembolic stroke.
Area of Science:
- Neurology
- Pediatrics
- Obstetrics
Background:
- Congenital hemiparesis can result from middle cerebral artery infarction.
- The precise cause of neonatal stroke is frequently unknown.
Observation:
- Two infants presented with imaging confirmation of middle cerebral artery infarction.
- Their mothers exhibited elevated anticardiolipin antibody levels post-delivery.
Findings:
- Maternal anticardiolipin antibodies may play a role in intrauterine thromboembolic stroke.
- This suggests a potential mechanism for stroke in infants with congenital hemiparesis.
Implications:
- Understanding the role of anticardiolipin antibodies can inform future research on stroke prevention.
- Early identification of risk factors may improve outcomes for infants with congenital hemiparesis.