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Meigs syndrome with elevated serum CA 125.

J Y Lin1, C Angel, J Z Sickel

  • 1Department of Obstetrics and Gynecology, University of Rochester School of Medicine, New York.

Obstetrics and Gynecology
|September 1, 1992
PubMed
Summary

Elevated CA 125 levels in Meigs syndrome may stem from peritoneal processes, not just ovarian cancer. This finding suggests a broader understanding of CA 125 expression in ascites-related conditions.

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Area of Science:

  • Gynecologic Oncology
  • Tumor Markers
  • Pathology

Background:

  • Serum CA 125 is a recognized marker for ovarian cancer.
  • Meigs syndrome, characterized by ovarian fibroma, ascites, and pleural effusion, can also elevate CA 125.
  • Previous reports noted CA 125 elevation in one Meigs syndrome case.

Observation:

  • Two new cases of Meigs syndrome presented with significantly elevated serum CA 125.
  • Immunohistochemical staining was performed to localize CA 125 expression.
  • CA 125 was found on omental and peritoneal surfaces.

Findings:

  • CA 125 expression was notably absent in the ovarian fibroma itself.
  • The localized expression suggests a peritoneal origin for the elevated CA 125.

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  • Ascites accumulation may be linked to a common peritoneal inflammatory or reactive process.

    • Implications:

    • This challenges the sole association of CA 125 elevation with ovarian malignancy.
    • It suggests CA 125 may indicate peritoneal involvement in conditions like Meigs syndrome.
    • Further research is warranted to explore peritoneal processes as a source of CA 125 in non-malignant conditions.