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Related Experiment Videos

Spreading depression and migraine.

M Lauritzen1

  • 1Department of General Physiology and Biophysics, University of Copenhagen, Panum Institute, Denmark.

Pathologie-Biologie
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

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Cortical spreading depression (CSD), a wave of brain inactivity, may be a mechanism behind migraine headaches. Targeting NMDA receptors could offer a new migraine treatment strategy.

Area of Science:

  • Neuroscience
  • Neurology
  • Migraine Research

Background:

  • Cortical spreading depression (CSD) is a transient wave of neural suppression across the cortex.
  • CSD involves ion imbalance, neuronal depolarization, and heightened energy metabolism.
  • Migraine prodromes share characteristics with CSD, suggesting a potential link.

Purpose of the Study:

  • To explore the hypothesis that cortical spreading depression (CSD) is a mechanism underlying migraine.
  • To investigate the role of N-methyl-D-aspartate (NMDA) receptors in CSD and migraine.

Main Methods:

  • Review of existing literature and experimental findings on CSD and migraine.
  • Comparison of neurophysiological and metabolic abnormalities observed in migraine patients and animal models of CSD.

Related Experiment Videos

  • Examination of experimental data linking CSD to NMDA receptor activity.

    • Main Results:

    • Migraine attacks exhibit unique brain blood flow, energy metabolism, and magnetoencephalography abnormalities.
    • These abnormalities in migraine patients have been successfully replicated in animal models during CSD.
    • CSD has been shown to be closely associated with the activity of NMDA-subtype glutamate receptors.

    Conclusions:

    • CSD is a plausible mechanism for migraine.
    • NMDA receptor antagonism presents a promising therapeutic target for rational migraine treatment.