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[Migraine and non-steroidal anti-inflammatory agents]
1Service de Médecine Interne, Hôpital Rothschild, Paris, France.
Pathologie-Biologie
|April 1, 1992
Summary
Nonsteroidal anti-inflammatory drugs (NSAIDs) effectively treat acute migraine attacks, showing significant improvement over placebo. While also showing promise for long-term migraine prevention, NSAIDs carry risks of gastrointestinal side effects with prolonged use.
Area of Science:
- Neurology
- Pharmacology
Background:
- Migraine is a common neurological disorder.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management.
Purpose of the Study:
- To review controlled studies on NSAIDs for acute migraine treatment and long-term prophylaxis.
- To evaluate the efficacy and safety of various NSAIDs in migraine management.
Main Methods:
- Systematic review of controlled studies comparing NSAIDs to placebo or reference drugs.
- Inclusion of studies on aspirin, ibuprofen, naproxen, diclofenac, and other NSAIDs.
Main Results:
- NSAIDs demonstrated significantly greater efficacy than placebo for acute migraine attacks.
- NSAIDs were found to be as effective as reference drugs for acute treatment with minimal adverse effects.
- Evidence suggests NSAIDs are valuable for migraine prophylaxis, though long-term use is linked to gastrointestinal issues.
Conclusions:
- NSAIDs are effective and well-tolerated for acute migraine attack management.
- NSAIDs show potential for migraine prophylaxis, but long-term safety concerns, particularly gastrointestinal, require consideration.