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Related Experiment Videos

The appendix in inflammatory bowel disease in children.

E Kahn1, J Markowitz, F Daum

  • 1Department of Laboratories, North Shore University Hospital, Cornell University Medical College, Manhasset, New York.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|July 1, 1992
PubMed
Summary

In pediatric inflammatory bowel disease (IBD), appendiceal involvement is common, with specific changes seen in over half of Crohn's disease and ulcerative colitis cases. All examined appendices showed abnormalities, indicating significant appendiceal pathology in children with IBD.

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Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Pathology
  • Inflammatory Bowel Disease

Background:

  • Appendiceal pathology in pediatric inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is not well-defined.
  • The frequency of appendiceal involvement in children with IBD requires further delineation.

Purpose of the Study:

  • To determine the prevalence of appendiceal involvement in children with IBD requiring colonic resection.
  • To define the histopathologic characteristics of the appendix in pediatric CD and UC.

Main Methods:

  • Retrospective analysis of 41 children with IBD (24 CD, 17 UC) who underwent colonic resection.
  • Histopathologic examination of all resected appendices.

Main Results:

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  • All appendices examined (100%) exhibited abnormalities.
  • Specific histopathologic changes consistent with CD or UC were identified in 50% and 56% of appendices, respectively.
  • Nonspecific changes, including fibrosis and hyperplasia, were observed in the remaining appendices. The severity of inflammation in the ileocolon and appendix was similar in approximately two-thirds of patients.

Conclusions:

  • Appendiceal involvement is a consistent finding in children with IBD requiring colonic resection.
  • Both specific and nonspecific appendiceal changes are prevalent in pediatric IBD, highlighting the appendix as a site of inflammation.
  • The appendix should be considered in the evaluation of pediatric IBD patients, as it frequently displays characteristic or nonspecific inflammatory changes.