Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Spotlight on vardenafil in erectile dysfunction.

Gillian M Keating1, Lesley J Scott

  • 1Adis International Limited, Auckland, New Zealand. demail@adis.co.nz

Drugs & Aging
|February 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction to: Afatinib in advanced NSCLC: a profile of its use.

Drugs & therapy perspectives : for rational drug selection and use·2019
Same author

Afatinib in advanced NSCLC: a profile of its use.

Drugs & therapy perspectives : for rational drug selection and use·2018
Same author

Ticagrelor: A Review in Long Term Secondary Prevention of Cardiovascular Events.

Drugs·2017
Same author

Eluxadoline: A Review in Diarrhoea-Predominant Irritable Bowel Syndrome.

Drugs·2017
Same author

Sorafenib: A Review in Hepatocellular Carcinoma.

Targeted oncology·2017
Same author

Delta-9-Tetrahydrocannabinol/Cannabidiol Oromucosal Spray (Sativex<sup>®</sup>): A Review in Multiple Sclerosis-Related Spasticity.

Drugs·2017
Same journal

Correction: Guideline-Directed Heart Failure Pharmacotherapy in Adults Aged ≥75 Years: Evidence Gaps, Tolerability, and Implications for Clinical Practice.

Drugs & aging·2026
Same journal

Targeted Treatment for Hyperuricemia: The Drug Pipeline.

Drugs & aging·2026
Same journal

Efficacy and Safety of Ciprofol Versus Propofol for Anesthesia in Older Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Drugs & aging·2026
Same journal

Leveraging Real-World Data for Clinical Decision Making in Geriatric Oncology.

Drugs & aging·2026
Same journal

Drug Utilisation of Fall-Risk-Increasing Drugs (FRIDs) and Risk of Hospitalisation: A Nested Case-Control Study Among Community-Dwelling Older Adults.

Drugs & aging·2026
Same journal

Gabapentinoid Use and Risk of Alzheimer's Disease-Related Dementias: A Systematic Review and Meta-analysis of Observational Studies.

Drugs & aging·2026
See all related articles

Vardenafil (Levitra) effectively treats erectile dysfunction (ED) in men. This phosphodiesterase type 5 inhibitor is well-tolerated and improves erectile function across various causes of ED.

Area of Science:

  • Pharmacology
  • Urology
  • Andrology

Background:

  • Erectile dysfunction (ED) affects men of varying aetiologies.
  • Phosphodiesterase type 5 (PDE5) inhibitors are a common treatment for ED.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of vardenafil in men with ED.
  • To assess vardenafil's impact on erectile function across different ED causes.

Main Methods:

  • Two randomized, double-blind, multicenter, fixed-dose studies.
  • 12 or 26 weeks duration for general ED; 3-month studies for ED in diabetes or post-prostatectomy.
  • International Index of Erectile Function (IIEF) and Sexual Encounter Profile (SEP) questionnaires were used.

Main Results:

Related Experiment Videos

  • Vardenafil significantly improved erectile function, penetration, and maintenance compared to placebo.
  • Improvements were noted in intercourse satisfaction and orgasmic function.
  • Vardenafil was generally well-tolerated with mild to moderate, transient adverse events like headache and flushing.

Conclusions:

  • Vardenafil is a potent and selective oral PDE5 inhibitor effective for mild to severe ED.
  • It is a suitable first-line treatment option for eligible men with ED, including those with diabetes or post-prostatectomy.
  • Vardenafil demonstrates good tolerability and efficacy in diverse patient populations.