Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Study of gene expression difference in lung carcinogenesis by cDNA microarray].

Zai-Mei Peng1, Fa-Qing Tang, E-Sheng Wu

  • 1Department of Respiratory Medicine,Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China. zaimeipg@hotmail.com

AI Zheng = Aizheng = Chinese Journal of Cancer
|February 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ferritin as a novel predictive index for nasopharyngeal carcinoma survival and therapeutic efficacy of different chemotherapy regimens.

World journal of clinical oncology·2026
Same author

Plakophilin 1 in cancer: context-dependent dualism, subcellular dynamics, and therapeutic targeting.

Frontiers in cell and developmental biology·2025
Same author

Integrated analysis of bulk and single-cell RNA sequencing reveals the interaction of PKP1 and tumor-infiltrating B cells and their therapeutic potential for nasopharyngeal carcinoma.

Frontiers in genetics·2022
Same author

The influence of UGT2B7 genotype on valproic acid pharmacokinetics in Chinese epilepsy patients.

Epilepsy research·2015
Same author

Cathepsins mediate tumor metastasis.

World journal of biological chemistry·2013
Same author

[Effect of Dahuangzhechong pill on the gene expression spectra of preventing arterial thrombosis].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials·2009
Same journal

A case of myxoid chondrosarcoma arising from caput costae.

Ai zheng = Aizheng = Chinese journal of cancer·2010
Same journal

[Vascular endothelial growth factor (VEGF)-D in association with VEGF receptor-3 in lymphatic metastasis of breast cancer].

Ai zheng = Aizheng = Chinese journal of cancer·2009
Same journal

[Progress on the subcellular localization of Daxx].

Ai zheng = Aizheng = Chinese journal of cancer·2009
Same journal

[Expression of B7-H1 protein in human pancreatic carcinoma tissues and its clinical significance].

Ai zheng = Aizheng = Chinese journal of cancer·2009
Same journal

[Clinical research on recombinant human Ad-p53 injection combined with cisplatin in treatment of malignant pleural effusion induced by lung cancer].

Ai zheng = Aizheng = Chinese journal of cancer·2009
Same journal

[Efficacy of cetuximab combined with chemotherapy on advanced colorectal cancer: a report of 53 cases].

Ai zheng = Aizheng = Chinese journal of cancer·2009
See all related articles

This study identified key genes like early growth response protein 1 (EGR1) and secreted apoptosis related protein 1 (SARP1) that are highly expressed in lung cancer tissues. These findings may aid in the early diagnosis and treatment of pulmonary carcinoma.

Area of Science:

  • Molecular Biology
  • Oncology
  • Gene Expression Analysis

Context:

  • Lung cancer presents high incidence and mortality with unclear molecular mechanisms.
  • Understanding gene expression is crucial for early diagnosis and targeted therapy.
  • This research analyzes gene expression in various lung tissue types.

Purpose:

  • To investigate gene expression differences in lung cancer, paracancerous, normal lung, and lymph node metastasis tissues.
  • To identify genes with relatively high expression in lung carcinoma.
  • To provide a theoretical basis for early diagnosis and treatment of pulmonary carcinoma.

Summary:

  • Gene expression profiling using cDNA microarray revealed differential expression in lung cancer tissues.
  • Upregulated genes in cancer tissues include EGR1 and SARP1; downregulated genes include MCL1.

Related Experiment Videos

  • Metastatic lymph nodes showed altered expression of genes related to adhesion and matrix metalloproteinases.

    • Impact:

    • Identifies potential key genes (e.g., EGR1, SARP1) in pulmonary carcinogenesis.
    • Highlights the role of MMP9 and TSP2 in lung cancer metastasis and infiltration.
    • Offers insights for developing novel diagnostic markers and therapeutic strategies for lung cancer.