Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emerging neuroskeletal signalling pathways: a review.

Gary J Spencer1, Ian S Hitchcock, Paul G Genever

  • 1Biomedical Tissue Research, Department of Biology, University of York, York YO10 5YW, UK. gjs6@york.ac.uk

FEBS Letters
|February 13, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

JAK2V617F reprograms Hypoxia Inducible Factor-1 to induce a non-canonical hypoxia regulon in myeloproliferative neoplasms.

Leukemia·2026
Same author

Molecular-Scale Tuning of Low-Molecular-Weight Gelators Controls Supramolecular Assembly and Directs Human Mesenchymal Stem Cell Growth.

Angewandte Chemie (International ed. in English)·2026
Same author

Thrombocytopenia in murine schistosomiasis is associated with platelet uptake by liver macrophages that have a distinct activation phenotype.

PLoS pathogens·2025
Same author

Extracellular vesicle bioactivity and potential for clinical development are determined by mesenchymal stromal cell clonal subtype.

Stem cell research & therapy·2025
Same author

Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA.

Science (New York, N.Y.)·2025
Same author

Diffusion-Patterned Multi-Component Supramolecular Gels Loaded with Gold Nanoparticles Direct Mesenchymal Stem Cell Growth and Differentiation.

Advanced healthcare materials·2025

Neurotransmitters significantly impact bone health by interacting with bone cells. This review explores the origins, targets, and functions of this crucial skeletal signalling network.

Area of Science:

  • Skeletal Biology
  • Neuroendocrinology
  • Cellular Signalling

Background:

  • Neurotransmitters, typically associated with the nervous system, are increasingly recognized for their roles beyond neuronal function.
  • Bone cells possess receptors and transporters for various neurotransmitters, indicating a direct mechanism for neural influence on skeletal tissue.
  • Evidence includes neuronal innervation of bone, neurotransmitter release by bone cells, and functional changes following pharmacological intervention.

Purpose of the Study:

  • To review the current understanding of neurotransmitter actions on the skeletal system.
  • To elucidate the origins of neurotransmitters relevant to bone.
  • To identify cellular targets and functional outcomes of neurotransmitter signalling in bone.

Main Methods:

Related Experiment Videos

  • Literature review of existing research on neurotransmitter-skeletal interactions.
  • Analysis of studies investigating neurotransmitter receptors and transporters in bone cells.
  • Synthesis of evidence from in vivo and in vitro experimental models.

Main Results:

  • Bone cells express a wide array of neurotransmitter receptors and transporters.
  • Activation of these receptors triggers intracellular signalling pathways that modulate bone cell function.
  • Neurotransmitter signalling represents a significant network influencing skeletal physiology.

Conclusions:

  • Neurotransmitter signalling is a key regulator of skeletal homeostasis.
  • Understanding this network offers potential therapeutic targets for bone diseases.
  • Further research is warranted to fully delineate the complexities of neuro-skeletal communication.