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Natasha Levenkova1, Qingjuan Gu, John J Rux

  • 1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.

Bioinformatics (Oxford, England)
|February 13, 2004
PubMed

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...