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Updated: Aug 26, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Stereoselective S N 2-substitutions using polyfunctional lithium arylcuprates prepared by an iodine-copper exchange
M Isabel Calaza1, Xiaoyin Yang, Darunee Soorukram
1Department Chemie, Ludwig-Maximilians-Universität, Butenandtstrasse 5-13, 81377, München, Germany.
Abstract:
[reaction: see text] Polyfunctional mixed lithium arylcuprates of the type (FG-Ar)(PhMe(2)CCH(2))CuLi obtained via iodine- or bromine-copper exchange with (PhMe(2)CCH(2))(2)CuLi react with cyclic 2-iodoallylic acetates with high S(N)2 selectivity. The addition of ZnBr(2) changes this selectivity and allows the performance of highly regioselective and enantioselective anti S(N)2' substitutions using open-chain allylic pentafluorobenzoates.
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