Related Experiment Videos
A general, selective, high-yield N-demethylation procedure for tertiary amines by solid reagents in a convenient
Thomas Rosenau1, Andreas Hofinger, Antje Potthast
1Institute of Chemistry, Christian-Doppler Laboratory, University of Natural Resources and Applied Life Sciences, Vienna, Austria. thomas.rosenau@.boku.ac.at
Organic Letters
|February 14, 2004
Abstract:
[reaction: see text] A traditional preparative chromatographic column can be used to achieve quantitative N-demethylation of tertiary N-methylamines and alkaloids. The filling is the crucial part and is loaded with different solid reagents in three reaction zones. The parent compound is charged on the column, and the neat N-demethylated secondary amine leaves the column some minutes later.