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Updated: Aug 10, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Inverted follicular keratosis simulating malignant melanoma
Graham A Thom1, Christopher J Quirk, Peter J Heenan
1Dermatology Department, Royal Perth Hospital, GPO Box X2213, Perth, WA 6847, Australia.
Abstract:
A 93-year-old woman was noted to have a single pigmented lesion on the posterior aspect of her neck. Clinical examination revealed a 12 x 8-mm flat lesion, with an irregular border and variegated pigmentation. Dermatoscopic examination revealed a lesion with multiple colours, featureless areas and black dots, suggestive of malignant melanoma. With a presumed clinical diagnosis of malignant melanoma, an elliptical excision was performed, with a 1-cm margin. However, histological examination revealed the unexpected diagnosis of pigmented inverted follicular keratosis.
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