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Granular cell basal cell carcinoma
Pavel Dundr1, Jirí Stork, Ctibor Povýsil
1Departments of Pathology and Dermatology, First Medical Faculty, Charles University, Prague, Czech Republic. pdundr@seznam.cz
The Australasian Journal of Dermatology
|February 14, 2004
Summary
A rare granular cell basal cell carcinoma (BCC) variant was identified in a nasal tumour. Immunohistochemistry confirmed the diagnosis, highlighting specific cellular markers for this BCC subtype.
Area of Science:
- Dermatopathology
- Oncology
- Histology
Background:
- Basal cell carcinoma (BCC) is the most common type of skin cancer.
- BCC typically presents as a pearly or waxy bump or a flat, flesh-colored or brown scar-like lesion.
- Complete excision is the standard treatment for BCC.
Observation:
- A 69-year-old woman presented with a 2-year history of a slowly growing nasal tumour.
- Clinical diagnosis was BCC, and complete excision was performed.
- Histological examination revealed features of BCC with central granular cytoplasmic changes.
Findings:
- Pathological diagnosis of granular cell BCC was made.
- Immunohistochemistry showed tumor cells were positive for Ber-EP4, cytokeratin AE1/AE3, and cytokeratin CAM 5.2.
- Granular cells were specifically positive for CD68 antigen (monoclonal antibody KP1), while negative for S100 protein.
Implications:
- This case expands the histopathological spectrum of basal cell carcinoma.
- Understanding the immunophenotype of granular cell BCC is crucial for accurate diagnosis.
- Further research may elucidate the origin and behavior of this rare BCC variant.