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Updated: Aug 26, 2026
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In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection
Published on: November 27, 2014
West Nile Virus inactivation by the solvent/detergent steps of the second and third generation manufacturing
J J Jakubik1, S M Vicik, M M Tannatt
1Wyeth BioPharma, Purification Process Development, Andover, MA 01810, USA.
Haemophilia : the Official Journal of the World Federation of Hemophilia
|February 14, 2004
Abstract:
West Nile Virus (WNV) was immediately and completely inactivated to below assay detection limits upon addition of solvent/detergent (S/D) to intermediate process pools of second and third generation B-domain deleted recombinant Factor VIII (BDDrFVIII; ReFacto, Wyeth, Cambridge, MA, USA). We verify that the S/D step provides robust enveloped virus inactivation (>5 log(10)) and functions as a WNV barrier.
