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Behavioural Pharmacology in Classical Conditioning of the Proboscis Extension Response in Honeybees Apis mellifera
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Diazepam attenuates conditioned histamine release in guinea pigs.

Masahiro Irie1, Shoji Nagata, Yutaka Endo

  • 1Institute for Occupational Health Sciences. Aichi Medical University, Nagakute-cho, Aichi 480-1195, Japan. irie@ihs.kyushu-u.ac.jp

International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
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Summary

Diazepam, a medication, was found to reduce histamine release in guinea pigs with asthma-like symptoms. This suggests a potential pharmacological approach to managing conditioned asthmatic responses.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Immunology

Background:

  • Classical conditioning can trigger physiological responses, including those relevant to asthma.
  • Histamine release plays a role in asthmatic reactions.
  • Investigating pharmacological interventions for conditioned responses is crucial.

Purpose of the Study:

  • To determine if diazepam can modulate odor-induced conditioned histamine release in a model of bronchial asthma.
  • To explore the potential of diazepam in attenuating classical conditioning-associated asthmatic responses.

Main Methods:

  • Ovalbumin-sensitized guinea pigs were used as a model for bronchial asthma.
  • Conditioning involved simultaneous inhalation of ovalbumin (unconditioned stimulus) and dimethylsulfide (conditioned stimulus).
  • Animals received intraperitoneal injections of saline or diazepam (2.5 or 5 mg/kg) before exposure to the conditioned stimulus.

Main Results:

  • Saline-injected animals showed significantly increased plasma histamine levels after conditioned stimulus exposure (P<0.05).
  • Diazepam (5 mg/kg) administration prevented the elevation of plasma histamine.
  • Statistical analyses confirmed diazepam's suppressive effect on conditioned histamine release.

Conclusions:

  • Diazepam attenuates conditioned histamine release in an asthma model.
  • Pharmacological mediation of classical conditioning-associated asthmatic responses is possible.
  • Findings suggest diazepam as a potential therapeutic agent for managing conditioned asthmatic reactions.