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Role of rotaviruses in children with acute diarrhea in Tehran, Iran

A H Zarnani1, Sh Modarres, F Jadali

  • 1Department of Virology, Pasteur Institute of Iran, Tehran, Iran. zarnani25@yahoo.com

Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology
|February 14, 2004
PubMed

Insights

Rotavirus is a significant cause of acute diarrhea in Iranian children under five. Immunization at birth may offer protection against this common childhood illness.

Area of Science:

  • Pediatrics
  • Virology
  • Public Health

Background:

  • Rotavirus infection is a leading cause of childhood morbidity and hospitalization globally.
  • Acute diarrhea remains a significant health concern for infants and young children worldwide.

Purpose of the Study:

  • To determine the prevalence and etiological role of rotaviruses in children with acute diarrhea in Tehran.
  • To identify risk factors and seasonal patterns associated with rotavirus gastroenteritis in pediatric populations.

Main Methods:

  • A monoclonal antibody-based enzyme immunoassay was used to detect rotavirus antigen in stool samples.
  • Stool specimens were collected from 704 children under five with diarrhea and 176 healthy controls.

Main Results:

  • Rotavirus antigen was detected in 15.3% of pediatric patients with acute diarrhea.
  • Infants aged 6-12 months were most commonly affected; rotavirus infection was less frequent in breast-fed infants.
  • Watery diarrhea was the predominant symptom, and detection rates peaked in spring.

Conclusions:

  • Rotavirus is a major etiological agent of acute diarrhea in children under five in Iran.
  • Early childhood immunization against rotavirus may be crucial for preventing symptomatic infections.
Abstract

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