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Published on: March 11, 2014
High prevalence of human papillomavirus type 58 in Mexican colposcopy patients
Maria del Refugio González-Losa1, Iván Rosado-Lopez, Nina Valdez-González
1Virology Laboratory, Regional Research Center, Dr. Hideyo Noguchi, Autonomous University of Yucatán, Avenida Itzaez con Calle 59 No. 490, Col. Centro, Mérida, Yucatan 97000, Mexico. glosa@tunku.uady.mx
Background:
Cervical cancer is the second most common cancer of the women worldwide. Infection with some genotypes of human papillomavirus is the most important risk factor associated to cervical cancer.
Objective:
To determine the prevalence and genotypes of papillomavirus in biopsies of women with squamous intraepithelial lesion and cervical cancer.
Study Design:
Two hundred sequential patients of colposcopy clinic were studied. HPV diagnosis was done by polymerase chain reaction using MY09/MY11 primers, for genotyping line blot hybridization was used.
Results:
A total of 186 women were beta globin positive; 104 (55.9%) had histology diagnosis of low-grade squamous intraepitelial lesions (LSIL), 67 (36.0%) high-grade squamous intraepitelial lesions (HSIL) and 15 (8.1%) invasive cervical cancer (IC). The prevalence of HPV was 56.4% (104/185); HPV 58 was founded in 28.5% of all positive women, HPV 16 in 25.7%, HPV 18 in 13.3%, HPV 33 in 11.4% and 31 in 8.5%. In all grades of the lesions HPV 58 was the most frequently.
Conclusions:
The high prevalence of HPV 58 among Mexican women with HSIL and IC, has important implications in prophylaxis.
