Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men.

Kevin D Monahan1, Iratxe Eskurza, Douglas R Seals

  • 1Division of Cardiology H047, The Milton S. Hershey Medical Center, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033-2390, USA. kmonahan@psu.edu

American Journal of Physiology. Heart and Circulatory Physiology
|February 14, 2004
PubMed
Summary

Oxidative stress contributes to age-related decline in cardiovagal baroreflex sensitivity (BRS) in men. Ascorbic acid (vitamin C) supplementation improved BRS in older men, suggesting a role for antioxidants.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fisetin Supplementation Attenuates Premature Vascular Aging Induced by Doxorubicin via Suppression of Cellular Senescence and Mitochondrial Oxidative Stress.

Aging cell·2026
Same author

Early women's health research on endurance exercise training and cardiovascular aging at the University of Colorado Boulder using the masters athlete model.

Journal of applied physiology (Bethesda, Md. : 1985)·2026
Same author

Senolytic Treatment With Fisetin Reverses Age-Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12.

Aging cell·2026
Same author

Sympathetic Neural Overactivation, Vascular Dysfunction, and Exercise Intolerance in Long-Term Survivors of Breast Cancer Treated With Doxorubicin and Trastuzumab-Based Chemotherapy.

Journal of the American Heart Association·2026
Same author

Translational studies of chronic supplementation with a mitochondria-targeted antioxidant to improve physical function with ageing.

The Journal of physiology·2026
Same author

Late-Onset Menopause Attenuates Aortic Stiffness in the Postmenopausal Period.

Hypertension (Dallas, Tex. : 1979)·2026

Area of Science:

  • Cardiovascular Physiology
  • Aging Research
  • Oxidative Stress Biology

Background:

  • Cardiovagal baroreflex sensitivity (BRS) naturally declines with age in healthy men.
  • Oxidative stress is implicated as a potential mechanism underlying this age-associated reduction.

Purpose of the Study:

  • To investigate the mechanistic role of oxidative stress in age-related decreases in cardiovagal BRS.
  • To determine if antioxidant intervention with ascorbic acid can mitigate this decline.

Main Methods:

  • Studied young and older healthy men.
  • Assessed cardiovagal BRS using the modified Oxford technique with pharmacological agents.
  • Administered intravenous ascorbic acid and re-assessed BRS.

Main Results:

Related Experiment Videos

  • Older men exhibited significantly lower baseline cardiovagal BRS compared to younger men (56% reduction).
  • Ascorbic acid infusion increased cardiovagal BRS in older men by 58% but had no effect in younger men.
  • Ascorbic acid administration did not alter baseline blood pressure, heart rate, or vascular compliance.

Conclusions:

  • These findings provide experimental evidence that oxidative stress contributes mechanistically to age-associated reductions in cardiovagal BRS.
  • Antioxidant intervention with vitamin C may be a potential strategy to improve baroreflex function in aging individuals.