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Clinical management of thrombophilia-related placental vascular complications

Benjamin Brenner1

  • 1Department of Hematology and Bone Marrow Transplantation, Rambam Medical Center, Haifa 31096, Israel. b_brenner@rambam.health.gov.il

Blood
|February 14, 2004
PubMed

Pregnancy is a hypercoagulable state with an increased thrombotic risk throughout gestation and the postpartum period. Women with thrombophilia may have a further increased risk of placental vascular complications, including pregnancy loss, preeclampsia, intrauterine growth restriction, and placental abruption. Preliminary data suggest that maternal antithrombotic prophylaxis may result in improved gestational outcome. Randomized trials are under way and hopefully will optimize maternal and neonatal outcome.

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