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Updated: Aug 7, 2026
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Published on: June 6, 2018
Cholinergic facilitation of erection and ejaculation in spinal cord-transected rats
V M Vargas1, D Torres, F Corona
1Departamento de Agrobiología, Universidad Autónoma de Tlaxcala, Tlaxcala, Mexico.
Abstract:
Penile reflexes (PRs) were monitored in chronic spinal cord-transected rats by identifying them visually, and at the same time they were recorded as the electromyographic activity of bulbospongiosus muscles. Intraperitoneal injection of the agonist muscarine (10 microg) produced a facilitation of PRs. A decrease in the latency, an increase in the number of clusters and often an increase in the duration of cups were found after muscarine. In addition, 66% (six out of nine) of the animals ejaculated after muscarine. These results suggest that cholinergic receptor stimulation may be involved in erectile and ejaculatory mechanisms mediated by the spinal cord.
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