Frequency of hypertension in chronic Chagas' disease: retrospective clinical study

Cristina Brandt Friedrich Martin Gurgel1, Armando Miguel Junior, Clayde Regina Mendes

  • 1Faculdade de Medicina, Pontifícia Universidade Católica de Campinas, SP, Brazil. cbfmgurgel@ig.com.br

Insights

Hypertension occurs in Chagas disease patients at rates similar to the general population. Cardiologic findings in these patients do not significantly differ from other Chagas disease patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Public Health

Background:

  • Chagas disease, caused by Trypanosoma cruzi, can lead to cardiac complications.
  • Hypertension is a common comorbidity in cardiovascular diseases.

Purpose of the Study:

  • To determine the prevalence of hypertension in patients with chronic Chagas disease.
  • To analyze the clinical behavior and cardiologic findings associated with hypertension in this population.

Main Methods:

  • Retrospective study of 225 patients with chronic Chagas disease and hypertension.
  • Data collected from 1984 to 2000, including clinical, electrocardiographic, and radiological assessments.

Main Results:

  • Hypertension prevalence was 33.3% among the studied Chagasic patients.
  • Cardiac enlargement was observed in 44.9% of cases; conduction disorders were also common.
  • The undetermined form of Chagas disease was most prevalent, followed by conduction disorders.

Conclusions:

  • The frequency of hypertension in Chagasic patients is comparable to the general population.
  • Clinical and cardiologic profiles of hypertensive Chagasic patients do not markedly differ from non-hypertensive Chagasic patients.
Abstract

Related Concept Videos

American Trypanosomiasis01:22

American Trypanosomiasis

Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...