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Therapeutic angiogenesis. Devising new strategies based on past experiences
Ye Lei1, Husnain Kh Haider, Jiang Shujia
1Department of Cardiothoracic and Vascular Surgery, National University Hospital, 5-Lower Kent Ridge Road, Singapore-119074.
Basic Research in Cardiology
|February 14, 2004
Summary
Therapeutic angiogenesis, using gene therapy and stem cells, shows promise for treating tissue ischemia and ischemic heart disease. Cellular approaches offer a novel strategy for revascularization, with ongoing clinical trials evaluating their effectiveness.
Area of Science:
- Regenerative Medicine
- Gene Therapy
- Cardiovascular Research
Background:
- Therapeutic angiogenesis aims to improve tissue ischemia by enhancing blood vessel formation.
- Current methods include growth factor proteins and gene transfer via various vectors.
- Cell-mediated gene transfer represents a novel and promising approach.
Purpose of the Study:
- To review the concept and evidence for therapeutic angiogenesis.
- To analyze cell-mediated gene transfer strategies for revascularization.
- To evaluate clinical perspectives and challenges for treating ischemic heart disease.
Main Methods:
- Review of pre-clinical studies and Phase I/II human trials.
- Focus on vascular endothelial growth factor (VEGF) and cellular angiogenesis.
- Analysis of genetically modified cells and stem cell therapies.
Main Results:
- Pre-clinical and early clinical data support the potential of therapeutic angiogenesis.
- Cellular approaches, including stem cells, demonstrate revascularization capabilities.
- VEGF-based therapies have been investigated in human trials.
Conclusions:
- Cell-mediated gene transfer is a viable strategy for therapeutic angiogenesis.
- Further research is needed to address challenges for clinical application in ischemic heart disease.
- Ongoing trials are crucial for establishing the efficacy and safety of these novel treatments.