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[Study on the anti-oxidation function of nucleic acids].

Qiuping Dai1, Shuguang Li, Jinming Yu

  • 1Department of Preventive Medicine, College of Basic Medical, Tongji University, Shanghai 200070, China.

Wei Sheng Yan Jiu = Journal of Hygiene Research
|February 18, 2004
PubMed
Summary

Nucleic acid supplements demonstrate anti-oxidation effects in aged rats by reducing malondialdehyde and increasing superoxide dismutase. In humans, nucleic acids improved vigor and appetite, suggesting potential health benefits.

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Area of Science:

  • Biochemistry
  • Gerontology
  • Nutritional Science

Background:

  • Oxidative stress is a significant factor in aging.
  • Nucleic acids play crucial roles in cellular function and repair.
  • Investigating the anti-oxidative properties of nucleic acids is important for understanding aging processes.

Purpose of the Study:

  • To evaluate the anti-oxidation effects of nucleic acid supplements in aged rats.
  • To assess the impact of nucleic acid supplementation on oxidative stress markers and general well-being in older adults.

Main Methods:

  • Aged female Sprague-Dawley rats were administered varying doses of nucleic acid capsules for 50 days, with serum oxidative stress markers (MDA, SOD, GSH-Px) measured.
  • 120 volunteers aged 50-65 received either nucleic acid capsules or a placebo for 60 days, with serum oxidative stress markers and subjective well-being indicators assessed.

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Main Results:

  • In rats, nucleic acid supplementation significantly reduced serum malondialdehyde (MDA) and increased superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) levels.
  • In humans, nucleic acid intake led to a significant increase in serum SOD and notable improvements in appetite, vigor, and energy compared to the control group.

Conclusions:

  • Nucleic acid supplementation exhibits significant anti-oxidation capabilities in aged rats.
  • Nucleic acids alone can enhance superoxide dismutase levels and improve subjective measures of well-being, such as appetite and energy, in older adults.