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Genetic Analysis Workshop II: segregation and three-locus linkage analysis
D T Bishop1, L A Cannon, S H Hasstedt
1Department of Human Genetics, University of Utah Medical Center, Salt Lake City, UT.
Abstract:
Data stimulated for Genetic Analysis Workshop II were analyzed using PAP. Segregation analysis showed a simple recessive mode of inheritance for data set 2 while no conclusions could be made about the mode of inheritance for data set 3. Pairwise linkage analysis suggested three linkage groups, but three-locus analysis did not provide strong evidence for the gene order within these groups. For three of the four three-locus comparisons performed, three-locus analysis suggested the simulated order. In only one case did the pairwise analysis suggest the simulated order, indicating the necessity for multi-locus analysis for gene order.
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