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Related Experiment Videos

Ageing, growth hormone and physical performance.

F Lanfranco1, L Gianotti, R Giordano

  • 1Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy.

Journal of Endocrinological Investigation
|February 18, 2004
PubMed
Summary

Ageing reduces growth hormone (GH) and IGF-I activity, impacting body composition. While exercise and GH therapies show promise, evidence for frail elderly benefiting from restoring GH/IGF-I levels remains limited.

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Area of Science:

  • Gerontology
  • Endocrinology
  • Exercise Physiology

Background:

  • Human ageing is linked to declining growth hormone (GH)/IGF-I axis activity, mirroring changes seen in younger adults with GH deficiency.
  • Age-related decline in GH/IGF-I is influenced by hypothalamic control, peripheral hormones, and metabolic factors, a phenomenon termed 'somatopause'.

Purpose of the Study:

  • To review the alterations in GH/IGF-I axis activity during ageing.
  • To examine the role of physical activity in regulating the GH/IGF-I axis.
  • To consider the effects of restoring GH and IGF-I levels on body composition and physical performance in the elderly.

Main Methods:

  • Literature review of studies on ageing, GH/IGF-I axis, physical activity, and related therapies.
  • Analysis of the impact of physical exercise on GH production and response in different age groups.

Related Experiment Videos

  • Evaluation of clinical trials using recombinant human GH (rhGH), recombinant human IGF-I (rhlGF-I), and GH-releasing molecules.

    • Main Results:

    • Physical exercise positively influences GH/IGF-I axis activity, though its efficacy diminishes with age.
    • GH therapy and GH-releasing agents have been explored for anti-ageing benefits, aiming to restore GH/IGF-I levels.
    • Current evidence does not definitively support significant benefits for frail elderly individuals from restoring GH/IGF-I levels to young adult ranges.

    Conclusions:

    • The GH/IGF-I axis undergoes significant age-related decline, affecting body composition and function.
    • Physical activity is a key regulator of the GH/IGF-I axis and offers benefits for older adults.
    • Further research is needed to establish the efficacy and safety of interventions aimed at restoring GH/IGF-I axis activity in the elderly.