[Morphological characteristics of chronic toxic hepatitis treated with neoselen]

The purpose of the given research work was to study the features of morphologic changes arising during the treatment of chronic hepatitis with NEOSELEN. Chronic active hepatitis was set up in laboratory rats, post-forming in chronic persisting hepatitis and its transformation in a certain part of animals into cirrhosis by administration of HELIOTRINE over the period of 40 days. Morphologically hepatic cirrhosis was small nodular. NEOSELEN was found to have a good therapeutic effect in treatment of chronic hepatitis as we have seen noticeable remittance of destructive necrotic changes in hepatic parenchymatouse elements and reduction in a volume of proliferative inflammatory infiltration along with acceleration of fibrosis process only in periportal zones of hepatic lobules. The therapeutic efficacy of NEOSELEN prevents transmission of chronic hepatitis into cirrhosis in a greater part of animals thus giving morphologic signs of importance of NEOSELEN in a restorative process of destructive and inflammatory changes in the affected liver.