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Related Experiment Videos

Developmental choices in mating-type interconversion in fission yeast.

A J Klar1

  • 1NCI-Frederick Cancer Research and Development Center, ABL-Basic Research Program, MD 21702-1201.

Trends in Genetics : TIG
|June 1, 1992
PubMed
Summary
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Trends in genetics : TIG·2001

Fission yeast cells exhibit programmed mating type switching. This developmental fate difference arises from asymmetric cell divisions and the inheritance of specific parental DNA strands during replication.

Area of Science:

  • Cell biology
  • Genetics
  • Developmental biology

Background:

  • Fission yeast (Schizosaccharomyces pombe) are a model organism for studying cell division and differentiation.
  • Cellular differentiation involves the inheritance of specific genetic material during cell division.
  • Understanding cell type switching is crucial for comprehending developmental processes.

Purpose of the Study:

  • To investigate the mechanism of mating type switching in fission yeast.
  • To elucidate the role of asymmetric cell division in determining cell fate.
  • To examine the contribution of DNA strand inheritance to developmental outcomes.

Main Methods:

  • Single-cell lineage tracing to observe cell type switching patterns.
  • Analysis of DNA replication and segregation during asymmetric cell divisions.

Related Experiment Videos

  • Genetic and molecular techniques to identify key regulatory factors.

    • Main Results:

    • Fission yeast cells demonstrate a predictable pattern of mating type switching within single-cell pedigrees.
    • Asymmetric cell divisions lead to daughter cells with distinct developmental fates.
    • The inheritance of specific parental DNA strands correlates with the observed cell type switching.

    Conclusions:

    • The inheritance of parental DNA strands during semiconservative replication and segregation dictates cell type switching in fission yeast.
    • Asymmetric cell division is a key mechanism driving differential cell fates.
    • This study provides insights into the fundamental processes governing cell differentiation and inheritance.