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Related Experiment Videos

Breast tuberculosis.

N Kalaç1, B Ozkan, H Bayiz

  • 1Atatürk Chest Disease and Chest Surgery, Training and Research Hospital, Ankara, Turkey.

Breast (Edinburgh, Scotland)
|February 18, 2004
PubMed
Summary

Breast tuberculosis is a rare condition, particularly in developed nations. Early diagnosis and treatment are crucial, especially in developing countries where it is more prevalent.

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Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Surgical Pathology

Background:

  • Breast tuberculosis is an uncommon manifestation of Mycobacterium tuberculosis infection.
  • Incidence rates range from 0.025% to 0.1% of surgically treated breast diseases, with higher prevalence in developing countries.
  • Often presents as unilateral breast lesions, predominantly in women of reproductive age who are breastfeeding.

Purpose of the Study:

  • To report on five cases of breast tuberculosis.
  • To highlight diagnostic challenges and treatment outcomes.
  • To emphasize the importance of considering breast tuberculosis in endemic regions.

Main Methods:

  • Case series presentation of five patients diagnosed with breast tuberculosis.
  • Diagnosis confirmed via histopathological examination of excisional biopsy specimens.
  • Microbiological investigations including Acid-Fast Bacilli (AFB) smear and culture were performed on various samples.

Main Results:

  • Five female patients aged 20–63 years presented with unilateral breast lesions (swelling or pain).
  • Histopathology revealed caseating granulomatous inflammation in breast tissue and axillary lymph nodes in three cases.
  • Acid-Fast Bacilli (AFB) were not detected in sputum, breast discharge, urine, or tissue cultures for any patient.
  • Standard antituberculosis therapy (2HRZE/4HR) was initiated; three patients completed treatment successfully.

Conclusions:

  • Breast tuberculosis, though rare, should be considered in the differential diagnosis of breast masses, particularly in developing and undeveloped countries.
  • Histopathological examination is key for diagnosis, as microbiological tests may be negative.
  • Prompt antituberculosis therapy is effective, though adherence and potential drug resistance require monitoring.

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