Photoallergic hand eczema due to benzydamine

Area of Science:

• Dermatology
• Allergology
• Toxicology

Background:

• Hand eczema is a common dermatological condition.
• Photoallergic reactions are hypersensitivity responses to substances activated by light.
• Benzydamine is a non-steroidal anti-inflammatory drug (NSAID) with analgesic and antiseptic properties.

Observation:

• A 65-year-old woman presented with a distinct rash on her hands.
• The rash was diagnosed as photoallergic eczema.
• The causative agent was identified as benzydamine, found in her prescribed gynecological washing solution.

Findings:

• The patient's hand eczema was triggered by topical exposure to benzydamine, exacerbated by sunlight.
• This case suggests benzydamine-induced photoallergic hand eczema may be an under-recognized cause of hand dermatitis.
• A thorough medical history (anamnesis) is crucial for diagnosing unusual dermatological conditions.

Implications:

• Clinicians should consider photoallergic reactions to topical medications, including benzydamine, in patients with hand eczema.
• Gynecological products containing benzydamine could be a potential source of iatrogenic photoallergic contact dermatitis.
• Emphasizes the diagnostic value of detailed patient history in identifying uncommon causes of skin conditions.