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Related Experiment Videos

Coexistent blepharospasm and hemifacial spasm: overlapping pathophysiologic mechanism?

E-K Tan1, L-L Chan, K-K Koh

  • 1Department of Neurology, Singapore General Hospital, Republic of Singapore. grntek@sgh.com.sg

Journal of Neurology, Neurosurgery, and Psychiatry
|February 18, 2004
PubMed
Summary

Blepharospasm (BEB) occurred more often in hemifacial spasm (HFS) patients than controls. This suggests shared brainstem pathways may contribute to these distinct movement disorders.

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Area of Science:

  • Neurology
  • Movement Disorders

Background:

  • Blepharospasm (BEB) and hemifacial spasm (HFS) are typically considered separate neurological conditions.
  • The clinical presentation and prevalence of coexisting BEB and HFS have not been well-documented.

Purpose of the Study:

  • To investigate the prevalence of coexisting blepharospasm (BEB) in patients with hemifacial spasm (HFS).
  • To examine the clinical and imaging characteristics of HFS patients who also have BEB.

Main Methods:

  • A cohort study involving 164 consecutive hemifacial spasm (HFS) patients and 501 age- and gender-matched controls.
  • Clinical assessment and advanced magnetic resonance imaging (MRI) and angiography were utilized.

Main Results:

  • Coexisting blepharospasm (BEB) was found in 5.5% of hemifacial spasm (HFS) patients, significantly higher than in controls (0%).

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  • Neurovascular compression was observed on the ipsilateral side in HFS patients, with no basal ganglia lesions identified.
  • BEB symptoms typically emerged after the onset of HFS.

    • Conclusions:

    • Blepharospasm (BEB) is more prevalent in hemifacial spasm (HFS) patients, indicating a potential link.
    • Altered brainstem blink reflex circuitry may play a role in the development of coexisting BEB and HFS in susceptible individuals.