Related Experiment Video
Updated: Jul 16, 2026

Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function
Published on: January 22, 2017
Into the depths of ataxia
1Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA. harry@lenti.med.umn.edu
Abstract:
Ataxia is a lethal neurological disease characterized by incoordination, postural abnormalities, difficulties with gait, and problems with clarity of speech. The etiology of ataxia is divided equally between hereditary and sporadic forms. Regardless of cause, the cerebellar cortex is often a target in ataxia. Thus, how a disruption in cerebellar cortex might lead to ataxia is of considerable interest. A report in this issue of the JCI links ataxia to enhanced hyperexcitability of neurons in the deep cerebellar nuclei.
Related Concept Videos
The Vestibular System
Major Somatic Sensory Pathways
Spinal Cord
Visual Agnosia
Dementia
The progression of dementia is generally gradual.
Ascites

