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Related Experiment Videos

Late effects surveillance system for sarcoma patients.

Thorsten Langer1, Wolfgang Stöhr, Stefan Bielack

  • 1LESS Center, University Hospital for Children and Adolescents, Department of Pediatric Oncology, Erlangen, Germany. less@kinder.imed.uni-erlangen.de

Pediatric Blood & Cancer
|February 18, 2004
PubMed
Summary

The Late Effects Surveillance System (LESS) pilot study found significant cardiotoxicity, ototoxicity, and nephrotoxicity in sarcoma patients within one year of treatment. This study demonstrates the feasibility of monitoring long-term treatment side effects.

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Area of Science:

  • Oncology
  • Pediatric Oncology
  • Clinical Pharmacology

Background:

  • A 1998 pilot study initiated the Late Effects Surveillance System (LESS) to monitor long-term effects in sarcoma patients.
  • Focus on Ewing sarcoma, osteosarcoma, and soft-tissue sarcoma survivors.

Purpose of the Study:

  • To assess the feasibility of the LESS methodology.
  • To investigate early (first-year) adverse effects following sarcoma treatment.

Main Methods:

  • Prospective, multicenter pilot study including 230 patients treated between 1998-1999.
  • Standardized, organ-specific screening methodology applied.
  • Analysis of toxicities within the first year post-therapy.

Main Results:

Related Experiment Videos

  • Cardiotoxicity: 12% of doxorubicin-treated patients showed reduced systolic heart function.
  • Ototoxicity: 7% of cisplatin-treated patients experienced hearing deficits.
  • Nephrotoxicity: 1% of ifosfamide-treated patients developed tubulopathy; 20% had reduced phosphate reabsorption.

Conclusions:

  • Significant short-term toxicities (cardiac, auditory, renal) observed within the first year after antineoplastic therapy.
  • The LESS methodology is feasible for monitoring late effects.
  • Further long-term follow-up is expected to reveal more major sequelae.