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Updated: Aug 11, 2026
Evaluation of Biomaterials for Bladder Augmentation using Cystometric Analyses in Various Rodent Models
Published on: August 9, 2012
[Experimental study on attachment of bacillus Calmette-Guerin to bladder wall with different types of injury]
Guo-qing Ding1, Zhou-jun Shen, Zhao-dian Chen
1Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou 310016, China.
Objective:
To investigate whether different types of injury on bladder wall can influence bacillus Calmette-Guerin (BCG) attachment.
Methods:
The bladder mucosa of 24 rabbits were treated by electrocautery,cryocautery and incision on left lateral wall, right lateral wall and posterior wall, respectively. Then radiolabeled BCG ((3)H-BCG) was instilled into bladder. Two hours latter, the injured bladder wall with different methods and non-injured wall (anterior wall of bladder) were surgically removed and digested. The quantity of BCG of each specimen was determined by liquid scintillation counter.
Result:
The quantity of BCG attachment to bladder wall with different injuries was significantly higher than that of non-injured wall (P<0.001), meanwhile there was no statistically difference among the BCG levels of different injury types (P>0.05).
Conclusion:
BCG attachment is not influenced by different types of injury on the bladder wall.
